- U-Haul Truck Rental, Irvine - U-Haul Moving
- U-Haul Trucks, Irvine - Uhaul Truck Rental
- U.S. Postal Service, Irvine
- Unfinished Furniture, Irvine
- Unfurnished Apartments, Irvine
- Uniforms, Irvine
- Uniforms Renting & Cleaning Service, Irvine
- Uniforms, Work Clothes & Safety Clothing, Irvine
- Unity Church, Irvine
- Unsupported Plastic Film & Sheet Manufacturers, Irvine
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- Used Appliances, Irvine
- Used Book Stores, Irvine - New & Rare Books
- Used Cars, Truck, Van & SUV Car Dealerships, Irvine
- Used Merchandise, Resale Shops & Thrift Stores, Irvine
- Utilities, Irvine
- Utilities Contractors, Irvine
- Utility & Waste Management Services, Irvine
- Utility Installation Contractors, Irvine
- Utility Vehicles - Sport & ATV, Irvine
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