- Safety Equipment & Supplies, Brawley
- Sand Gravel & Aggregate, Brawley
- Sandwich Shop Restaurants, Brawley
- Scaffolding & Aerial Lifts, Brawley
- Scales Public, Brawley
- Scales Retail, Brawley
- Scientific Services, Brawley
- Screen Printing, Brawley
- Screens Doors & Windows, Brawley
- Secondary Schools, Brawley
- Security & Surveillance System & Equipment, Brawley
- Security Brokers & Dealers, Brawley
- Seed & Grain Cleaning, Brawley
- Seeds & Bulbs Wholesale & Growers, Brawley
- Senior Citizens Information & Services, Brawley
- Sewer & Drain Cleaning & Repair, Brawley - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Brawley - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Brawley
- Shopping & Shopping Services, Brawley
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- Signs, Brawley
- Snacks & Desserts, Brawley
- Snow Cone Stands, Brawley
- Snow Cones, Brawley
- Social Services & Welfare, Brawley
- Speciality Food Stores, Brawley
- Specialty Animal Services, Brawley
- Specialty Goods Storage, Brawley
- Specialty Stores, Brawley
- Sprinkler System Contractors, Brawley - Garden & Lawn Sprinkler System Installation & Repair
- Staffing & Support Services, Brawley
- State Government, Brawley
- Stock & Bond Brokers & Dealers, Brawley
- Stock Yards, Brawley
- Stocks & Bond Brokers, Brawley
- Store Fixtures & Display Equipment, Brawley
- Sugar Refiners, Brawley
- Support Services, Brawley
- Surgical Hospitals, Brawley - Surgical Centers
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