- Salvation Army, Lake Isabella
- Sandwich Shop Restaurants, Lake Isabella
- Satellite Communication Downlinking & Uplinking, Lake Isabella
- Satellite Dish Antennas & Equipment Dealers, Lake Isabella
- Satellite TV Service, Lake Isabella
- Savings Banks, Lake Isabella
- Security Brokers & Dealers, Lake Isabella
- Senior Citizens Centers & Meals, Lake Isabella
- Senior Citizens Information & Services, Lake Isabella
- Senior Citizens Service & Health Organizations, Lake Isabella
- Septic Tank Installation & Repair, Lake Isabella - Septic Systems
- Septic Tank Pumping & Cleaning, Lake Isabella - Septic Systems
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- Septic Tanks & Septic Systems Contractors, Lake Isabella - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Shopping & Shopping Services, Lake Isabella
- Smoked Meat Restaurants, Lake Isabella
- Social Services & Welfare, Lake Isabella
- Societies & Foundation Associations, Lake Isabella
- Specialty Stores, Lake Isabella
- Sporting Goods Stores, Lake Isabella
- Staffing & Support Services, Lake Isabella
- Stock & Bond Brokers & Dealers, Lake Isabella
- Stocks & Bond Brokers, Lake Isabella
- Storage - Household & Commercial-Full Service, Lake Isabella
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