- Obstetricians & Gynecologists, Mission Viejo - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Mission Viejo
- Off Road Vehicles Parts & Accessories, Mission Viejo
- Office Buildings & Parks, Mission Viejo
- Office Supplies, Equipment & Office Furniture Stores, Mission Viejo
- Oil & Petroleum Products, Mission Viejo - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Mission Viejo - Auto Oil & Quick Lube
- Ophthalmologists, Mission Viejo - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Mission Viejo
- Opticians, Mission Viejo
- Optometrists, Mission Viejo - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Mission Viejo - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Iron Work, Mission Viejo
- Ornamental Nursery, Mission Viejo
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- Ornamental Nursery Services, Mission Viejo
- Orthodontist, Mission Viejo - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic Appliances, Mission Viejo
- Orthopedic Shoes, Mission Viejo
- Orthopedists, Mission Viejo - Orthopedic Surgery Doctors, Physicians & Surgeons
- Orthotics and Prosthetics, Mission Viejo
- Other Building Materials & Supplies, Mission Viejo
- Other Industrial Contractors, Mission Viejo
- Outdoor & Lawn & Garden Equipment Repair & Service, Mission Viejo
- Outdoor Equipment & Accessories, Mission Viejo
- Outdoor Furniture & Patio Furniture, Mission Viejo - Garden Furniture Stores
- Outerwear Stores, Mission Viejo - Jackets, Sunglasses, Hats, Caps, Coats, Gloves & More
- Outpatient Services, Mission Viejo - Outpatient Care
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