- Off Road Vehicles, Placerville
- Off Road Vehicles Parts & Accessories, Placerville
- Office Buildings & Parks, Placerville
- Office Supplies, Equipment & Office Furniture Stores, Placerville
- Oil & Gas Companies, Placerville
- Oil & Petroleum Products, Placerville - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Placerville - Auto Oil & Quick Lube
- Ophthalmologists, Placerville - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Repair & Service, Placerville - Camera Repair
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Placerville
- Optometrists, Placerville - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Placerville - Dentists - Oral & Maxillofacial Surgeons
- Orchard Equipment, Placerville
- Ornamental Iron - Residential, Placerville - Wrought Iron Work Supplies, Parts, Gates, Railings, Stairs, Spirals, Fence, etc
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- Ornamental Metal Work, Placerville - Steel, Iron, Bronze, etc
- Ornamental Nursery, Placerville
- Ornamental Nursery Products, Placerville
- Ornamental Nursery Services, Placerville
- Orthodontist, Placerville - Teeth Straightening, Invisalign & Dental Braces
- Other Building Materials & Supplies, Placerville
- Other Lodging, Placerville
- Other Office Supply Stores, Placerville
- Outdoor & Lawn & Garden Equipment Repair & Service, Placerville
- Outdoor Equipment & Accessories, Placerville
- Outdoor Furniture & Patio Furniture, Placerville - Garden Furniture Stores
- Outpatient Clinics, Placerville - Care & Treatment Centers
- Ownership Organizations, Placerville
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