- Safety & Security Systems & Consultants, Portola
- Sand Gravel & Aggregate, Portola
- Sandwich Shop Restaurants, Portola
- Screen Printing, Portola
- Seafood Restaurants, Portola
- Secondary Schools, Portola
- Security Brokers & Dealers, Portola
- Security Services, Portola
- Septic Tanks & Septic Systems Contractors, Portola - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewer & Drain Cleaning & Repair, Portola - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Portola
- Sheet Metal, Portola
- Sheet Metal Contractors, Portola - Sheet Metal Fabrication
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- Sheet Metal Fabricators & Ductwork Contractors, Portola
- Sheet Metal Work - Aluminum, Tin, Stainless Steel, etc, Portola - Sheet Metal Products
- Shopping & Shopping Services, Portola
- Smog Check, Brake & Lamp Inspection & Repair, Portola
- Social Services & Welfare, Portola
- Societies & Foundation Associations, Portola
- Solar Energy Companies - Contractors, Portola - Solar Panel Installation - Solar Power Systems
- Solar Products & Services, Portola
- Specialty Animal Services, Portola
- Specialty Stores, Portola
- Steak House Restaurants, Portola
- Surveyor Services, Portola - Surveying Service
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